Anti-KMT1E/SETDB1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Supplier: Bioss
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BS-11670R-A750
BOSSBS-11670R-A750EA 820 GBP
BOSSBS-11670R-A750
Anti-KMT1E/SETDB1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antibodies
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1More Product Information
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SPECIFICATIONS

Environmentally Preferable
Antigen name KMT1E/SETDB1
Antigen synonyms ESET|KMT1E|ERG-associated protein with SET domain|SET domain bifurcated 1|Histone-lysine N-methyltransferase SETDB1|KIAA0067|Lysine N-methyltransferase 1E|TDRD21|Histone H3-K9 methyltransferase 4|KG1T|SETDB1|H3-K9-HMTase 4|H3-K9-HMTase4
Antibody type Primary
Clonality Polyclonal
Conjugation Alexa Fluor® 750
Reactivity Rat
Host Rabbit
Gene ID 9869
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Modification Unmodified
Epitope 201-300/1291
Immunogen KLH conjugated synthetic peptide derived from human SETDB1
Form Liquid
Molecular weight 143 kDa
Purification Purified by Protein A
Concentration 1 µg/µl
Storage buffer Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Storage temperature Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Shipping temperature 4 °C
Tested applications ICC

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