Aluminon, powder, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY
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Synonyms: Ammonium 5,5'-((3-carboxylato-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoate)Aurin Tricarboxylic Acid Ammonium Salt

M-Clarity™ quality level = MQ200

A0885-25GEA 72.6 GBP
A0885-25G
Aluminon, powder, Sigma-Aldrich®
Aluminon

Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.


Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Formula: C₂₂H₂₃N₃O₉
MW: 473.44 g/mol
Melting Pt: 220...225 °C (dec.) (lit.)
MDL Number: MFCD00040925
CAS Number: 569-58-4
EINECS: 209-319-1
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Specification Test Results

Appearance (Colour) Dark Brown to Very Dark Brown and Dark Red to Very Dark Red and Very Dark Red-Brown
Appearance (Form) Powder
Solubility (Colour)
100 mg/ml in water
Dark Red
Water Report Result
Carbon Content Report Result
Carbon Content Report Result
Nitrogen Content Report Result
Application Test
Sensitivity to Aluminium Passes Test
Corresponds to Requirements

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