KN-93 ≥95% (by TLC)
Supplier: ENZO LIFE SCIENCES AGTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
Synonyms:
N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
, N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
CaM kinase inhibitor
KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC50=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Formula:
C₂₆H₂₉ClN₂O₄S MW: 501.04 g/mol |
MDL Number:
MFCD00236424 CAS Number: 139298-40-1 |
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