Rotenone ≥95.0% (by HPLC), Sigma-Aldrich®

Supplier: Merck
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

Danger


M-Clarity™ quality level = MQ200

R8875-10G R8875-1G R8875-25G R8875-5G
SIALR8875-10GEA 583 GBP
SIALR8875-10G SIALR8875-1G SIALR8875-25G SIALR8875-5G
Rotenone ≥95.0% (by HPLC), Sigma-Aldrich®
Rotenone

Inhibitor of mitochondrial electron transport at NADH: ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone is used to induce a parkinson-like syndrome as an experimental model in rats.


Rotenone has been used to to study its effect on cell proliferation, to detect the production of cellular reactive oxygen species in isolated rat forebrain mitochondria and to measure mitochondrial enzymatic activity.


Rotenone belongs to the retinoid family. It is naturally present in leguminosa plants and is considered to be cytotoxic. It is commonly used as an insecticide and a pesticide.


Inhibitor of mitochondrial electron transport. Neurotoxic agent that can produce a Parkinson-like condition as an animal model for study of etiology and intervention.

Formula: C₂₃H₂₂O₆
Boiling Pt: 210...220 °C (0.5 mmHg) (lit.)
Melting Pt: 159...164 °C (lit.)
MDL Number: MFCD09025614
CAS Number: 83-79-4
EINECS: 201-501-9
UN: 2811
ADR: 6.1,III

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Specification Test Results

Appearance (Colour) White to Yellow
Appearance (Form) Powder
Solvent Content by NMR ≤4%
Carbon 66.5 - 71.5%
Specific Rotation, C=1.39 in Chloroform at 25 °C –122 - –114°
Purity (HPLC) ≥95.0%

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