Brefeldin A 10 mg/ml in DMSO (from Penicillium brefeldianum) ≥98.00% (by HPLC) ready-to-use, Sigma-Aldrich®
Supplier: MerckTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
Synonyms:
(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one
, Brefeldin A, natural
M-Clarity™ quality level = MQ200
Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.
Hygroscopic. Soluble in DMSO (10 mg/ml).
Sterility: 0,2 μm filtered
Caution: Store under inert gas. Storage class (TRGS 510): Combustible liquids
Formula:
C₁₆H₂₄O₄ MW: 280.4 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00083258 CAS Number: 20350-15-6 |
Specification Test Results
Concentration | 10.000 - 10.500 mg/ml |
Purity (HPLC) | ≥98.00% |
Vapor Pressure | 0.56 hPa ( 20 °C) |
Autoignition Temperature | 301 °C |
Antibiotic Activity Spectrum | Neoplastics |
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