Brefeldin A 10 mg/ml in DMSO (from Penicillium brefeldianum) ≥98.00% (by HPLC) ready-to-use, Sigma-Aldrich®

Supplier: Merck
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Total Ratings: 0
Avg. Ratings: 0.0 out of 5

Synonyms: (1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-oneBrefeldin A, natural

M-Clarity™ quality level = MQ200

SIALB5936-200ULEA 203 GBP
SIALB5936-200UL
Brefeldin A 10 mg/ml in DMSO (from Penicillium brefeldianum) ≥98.00% (by HPLC) ready-to-use, Sigma-Aldrich®
Brefeldin A

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.


Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.


Hygroscopic. Soluble in DMSO (10 mg/ml).


Sterility: 0,2 μm filtered


Caution: Store under inert gas. Storage class (TRGS 510): Combustible liquids

Formula: C₁₆H₂₄O₄
MW: 280.4 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00083258
CAS Number: 20350-15-6

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Specification Test Results

Concentration 10.000 - 10.500 mg/ml
Purity (HPLC) ≥98.00%
Vapor Pressure 0.56 hPa ( 20 °C)
Autoignition Temperature 301 °C
Antibiotic Activity Spectrum Neoplastics

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