Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (Reference: uniprot.org)
Western Blotting (WB): 1:5,000 - 1:10,000. Casein kinase 1 alpha has a predicted molecular weight of 38 kDa.
Immunocytochemistry (ICC): 1:500-1:1,000.
Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: CK1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Shortest isoform of recombinant full length CK1a.
Host: Chicken
Isotype:
Reactivity: Human;Rat