Anti-RRM2 Rabbit Polyclonal Antibody

Supplier: Bioss
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BOSSBS-7133REA 648 GBP
BOSSBS-7133R
Anti-RRM2 Rabbit Polyclonal Antibody
Antibodies
Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage.

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Type: Primary
Antigen: RRM2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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