Anti-CD4 Mouse Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: OKT4]

Supplier: Tonbo Biosciences
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

65-0048-T100EA 117 GBP
65-0048-T100 65-0048-T025
Anti-CD4 Mouse Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: OKT4]
Antibodies
The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).

Type: Primary
Antigen: CD4 (CD4 molecule)
Clonality: monoclonal
Clone: OKT4
Conjugation: Peridinin Chlorophyll/Cy5.5®
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity:
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR