Anti-KLRG1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 2F1]

Supplier: Tonbo Biosciences
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

50-5893-U025 50-5893-U100
50-5893-U025EA 54.9 GBP
50-5893-U025 50-5893-U100
Anti-KLRG1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 2F1]
Antibodies
The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

Type: Primary
Antigen: KLRG1 (killer cell lectin-like receptor subfamily G, member 1)
Clonality: monoclonal
Clone: 2F1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Mouse
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR