Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]

Supplier: Tonbo Biosciences
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

35-1152-U025 35-1152-U100
35-1152-U025EA 58.9 GBP
35-1152-U025 35-1152-U100
Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]
Antibodies
The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerisation of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralisation of CSF-1 Receptor (use format appropriate for functional assays).

Type: Primary
Antigen: CSF1R (colony stimulating factor 1 receptor)
Clonality: monoclonal
Clone: AFS98
Conjugation: FITC (Fluorescein)
Epitope:
Host: Rat
Isotype: IgG2a Kappa
Reactivity: Mouse
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR